Microsatellite Instability in Colorectal Cancer: Overview of Its ...
Microsatellite instability (MSI) is a key biomarker in colorectal cancer (CRC), with crucial diagnostic, prognostic, and predictive implications. Testing for mismatch repair deficiency …
Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer
Dec 2, 2020 · The efficacy of PD-1 blockade as compared with chemotherapy as first-line therapy for MSI-H–dMMR advanced or metastatic colorectal cancer is unknown.
Microsatellite Instability-High (MSI-H) Colon Cancer - WebMD
Learn more about the symptoms, causes, and treatment of this colon cancer type that involves a large number of gene mutations.
Microsatellite instability high biomarker (MSI-H) and colorectal cancer
Jun 24, 2025 · What is an MSI-H Biomarker? MSI-H and MSS biomarkers indicate the stability of the DNA in a tumor. Colorectal cancer tumors are often referred to as having an “MSI status,” …
What is microsatellite instability? - MD Anderson Cancer Center
Mar 6, 2023 · When you’re diagnosed with cancer, your doctor may refer to whether the cancer has microsatellite instability (MSI). Gastrointestinal medical oncologist and researcher Jason …
Pathology Outlines - Microsatellite instability pathway
Oct 8, 2025 · Microsatellite instability (MSI) is one of the pathways implicated in colorectal adenocarcinoma (CRC) carcinogenesis; colorectal cancer with MSI is referred to as MSI / …
Microsatellite Instability: What Is MSI Testing?
Aug 1, 2024 · High (MSI-H): Tumors have a high MSI if at least two of the five markers show instability. In patients with colorectal cancer, high MSI means the patient is likely to have …
MSI High and Colon Cancer: What is It, Treatment, and More
Feb 2, 2021 · Around 15 percent of colon cancer is MSI-high. Here's what that means, along with treatment options for the disease.
MSI-high colon cancer: Definition, outlook, and more
Jun 16, 2023 · MSI-high colon cancer cells have a large number of genetic mutations. Overall, MSI-high colon cancers are fairly uncommon. They typically respond well to immunotherapy …
Treating Patients With MSI-H BRAFV600E-Mutated Metastatic Colorectal Cancer
Mar 10, 2022 · Dr. Thierry André Key Points: One-fourth of BRAFV600E metastatic colorectal cancer (mCRC) are microsatellite instability–high (MSI-H), and one-fifth of MSI-H mCRC …